MINOCYCLINE- Broad spectrum tetracycline antibiotic

MECHANISM OF ACTION 

Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in bacterial membranes. Tetracycline like minocycline bind to the 30s ribosomal subunit, preventing the binding of tRNA to the Mrna-ribosonme complex and interfering with protein synthesis. 

USES

• Antibacterial
• Stomatological prepration 
• Alimentary tract and metabolism
• Antiseptic for local oral treatment 
• Broad -spectrum tetracycline antibiotic

SIDE EFFECTS 

• Amoebic dysentery
• Dizziness
• cholera
• Urinary tract infection 
• Headache and vomiting
• Mouth sores
• Upset stomach and fever
• Respiratory infection
• Bubonic plague
• Perioral dermatitis

DRUG DRUG INTERACTION

• Minocycline + alfentanil = minocycline may increase the CNS depressant activity of    alfentanil
• Minocycline+ alprazolam = minocycline may increase the CNS depressant activity of    alprazolam
• Minocycline + aluminium hydroxide = aluminium hydroxide can cause decrease in      absorption of minocycline
• Minocycline + amdilocillin = the therapeutic efficacy of amdilocillin can be decreased.
• Minocycline + amoxapin = minocycline may increase CNS depressant activity of   amoxapin.

REFERENCE

Tripathi K.D,"Essentials of medical pharmacognosy",7th edition,page no-734,735