Penfluridol-antipsychotic drug and its pharmacology

Introduction

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968.

Therapeutic Uses

-Analgesic

-Anti Convulsant

-Anti Depressant

-Anti Migraine

-Neuropathic pain

-Hypnotics

Side effects

-Blood dyscrasias

-Dry mouth

-Blurring vision

-Retention of urine

-Granular deposits in cornea

-Weight gain

Mechanism of action

Penfluridol blocks the postsynaptic dopamine receptor in the mesolimbic dopaminergic system and inhibits the release of hypothalamic and hypophyseal hormones.

Drug-drug interaction

1-Penfluridol+MAOIs= Orthostatic hypotension

2-Penfluridol+Metoclopramide= May increase risk of extrapyrimidal symptom

3-Penfluridol+Amphetamine= May increase psychosis

4-Penfluridol+Levodopa= May inhibit antiparkinsonian effect

REFERENCE:

Tripathi K.D,"Essentials of medical pharmacology",7th edition,page no 441,436