LACTULOSE-
MECHANISM OF ACTION:
▪ Lactulose is a synthetic sugar, consists of the monosaccharides fructose and galactose.
▪ In the colon, lactulose is broken down primarily to lactic acid and also to small amounts of formic acid and acetic acids, by the action of beta- galactosidase from colonic bacteria, which results in an increase in osmotic pressure and slight acidification of colonic contents.
▪ It causes an increase in stool water content and sofens the stool.
▪ It is uses in the treatment of constipation and liver disease.
REFERENCE:Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no.676-677.
MECHANISM OF ACTION:
▪ Lactulose is a synthetic sugar, consists of the monosaccharides fructose and galactose.
▪ In the colon, lactulose is broken down primarily to lactic acid and also to small amounts of formic acid and acetic acids, by the action of beta- galactosidase from colonic bacteria, which results in an increase in osmotic pressure and slight acidification of colonic contents.
▪ It causes an increase in stool water content and sofens the stool.
▪ It is uses in the treatment of constipation and liver disease.
REFERENCE:Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no.676-677.
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